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Genotip I. razreda glavnog sustava histokompatibilnosti kao prognostički čimbenik liječenja kroničnog hepatitisa C interferonom

Fakulteti, doktorske disertacije Vrsta gradje
Naslov
Genotip I. razreda glavnog sustava histokompatibilnosti kao prognostički čimbenik liječenja kroničnog hepatitisa C interferonom : doktorska disertacija / Ivo Ivić ; [voditelj rada Nikola Bradarić]. -
Impresum
Split : I. Ivić, 2007. ([s. l. : s. n.]). -
Materijalni opis
80 listova : ilustr. u bojama, graf. prikazi (pretežno u bojama) ; 30 cm + 1 optički disk. -
Jezik
hrv, eng
Napomena
Na vrhu nasl. str.: Sveučilište u Splitu, Medicinski fakultet....
Bibliografija: listovi 57-79. Summary.

SUMMARY

Objective.
The aim of the study was to evaluate association between human leukocyte antigens (HLA) class I and therapeutic response to interferon-.
In Croatian patients with chronic hepatitis C. Methods. HLA-A,B,C genotyping was done in 55 patients with sustained virological response and in 57 patients without sustained virological response to interferon-. therapy.
Examinees were treated in the period from 1998-2001 with interferon-. at dose of 3 million units three times a week.
Patients that after 12 weeks of therapy became hepatitis C virus RNA negative completed 48 weeks of therapy. Results.
There was no association between therapeutic outcome and frequency of HLA-A, as well as of HLA-B alleles.
HLA-Cw07 was significantly more frequent in patients with than in patients without sustained virological response (P< 0.050).

Conclusion.
In Croatian patients with chronic hepatitis C finding of HLA-Cw07 is predictor of sustained virological response to interferon-. therapy.

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