Značenje nalaza DNA humanih papiloma virusa u patohistološkom materijalu spontanih pobačaja s aneuploidijom u roditelja s urednim konstitucijskim kariotipom : doktorska disertacija

Fakulteti, doktorske disertacije
Naslov
Značenje nalaza DNA humanih papiloma virusa u patohistološkom materijalu spontanih pobačaja s aneuploidijom u roditelja s urednim konstitucijskim kariotipom : doktorska disertacija / Vida Čulić ; [voditelj rada Dragan Primorac]. -
Impressum
Split : V. Čulić, 2008. ([s. l. : s. n.]). -
Materijalni opis
131 list : graf. prikazi ; 30 cm + 1 optički disk. -
Jezik
hrv, eng
Napomena
Na vrhu nasl. str.: Sveučilište u Splitu, Medicinski fakultet.
Bibliografija: 106-128. Summary: The importance of DNA analysis of the human papilloma virus in patohystological material of spontaneous abortions with aneuploidy in parents with normal constitutional karyotypes.

SUMMARY

The importance of DNA analysis of the human papilloma virus in patohystological material of spontaneous abortions with aneuploidy in parents with normal constitutional karyotypes.
An abortion is the most frequent complication of pregnancy. Among other various causes, it seems that chromosome aberrations and viral infections come first.
The purpose of this research is to establish the hypothesis that two hits are responsible for aneuploidy which results in spontaneous abortion.
The first hit could have been triggered by patient’s former diseases of urinary and/or genital system.
The number of spontaneous abortions recorded in their siblings of second generations creates predisposition that may end with termination of pregnancy.
The second hit is usually triggered by chronic presence of EBV virus in male or/and female partner.
It has been demonstrated that there is no significant relation between the age of male or female partners and the number of spontaneous abortions.
Both males and females had former urinary or/and genital infections and the number of spontaneus abortions among the siblings of second generation is twice as high in relation to average population.
Variations in constitutional karyotypes (per inv 9, 9qh+) are also evident as well as presence of antibodies for EBV, CMV, or
HSV2 viruses.
Reactivation of latent EBV infection provides possibility for second hit.
Aneuploidy or tetraploidy is found at 23% of samlpes. The presence of HPV genome in placenta tissue is not verified.
Although we could not verify the presence of HPV virus in analysed tissue, it is clearly evident from statistical data that EBV and other viruses triggered the second hit, so it is possible that HPV could be one of triggers in the teory of two hits.

Therefore we think that the presumed hypothesis of two hits is clearly established.
The second hit causes a series of molecular and imunological changes, including changes in spindle apparatus during meiosis or in later mitotic divisions.

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